To avoid the timeconsuming manual configuration of a proxy server on all computers, phones and tablets, the proxy configuration can be provided automatically via DHCP by using WPAD.

For this setup, the following components are needed:

1. A DHCP server which announces DHCP option 252 with the URL of the PAC file (wpad.dat).
2. A webserver which serves the wpad.dat file
3. A wpad.dat PAC file where the Proxy IP is defined

On a MikroTik system, the DHCP server configuration looks like this:

/ip dhcp-server option
add code=252 name=local-pac-server value="http://192.168.0.2:80/wpad.dat\?"
/ip dhcp-server network
add address=192.168.0.0/24 dhcp-option=local-pac-server dns-server=192.168.0.1 gateway=192.168.0.1 netmask=24

Please note the trailing questionmark in the URL for the PAC file. This is a workaround for yet another occurrence of RFC nitpicking where some implementations might misinterpret the DHCP option and add an encoded NULL-byte character to the end of the URL when requesting the PAC file from the webserver.
With the questinmark at the end of the URL, any additional trailing NULL-byte character will be ignored by the webserver and the PAC file will be loaded just fine.

Following the example above, on the machine 192.168.0.2, we serve the following wpad.dat file:

function FindProxyForURL ( url, host ) {
	return "PROXY 1.2.3.4:8080; DIRECT";
}

With this setup, all systems will use the proxy at 1.2.3.4 and if the proxy is not available try to connect directly to the Internet.
While this is fine for a home network where the proxy is mostly used for adblocking, you probably want to remove the DIRECT part in an enterprise setup.